About Rituxan

Rituxan® (rituximab) in combination with glucocorticoids is the only FDA-approved induction therapy for adults with GPA and MPA, and may help put your condition into remission. Only your doctor can diagnose GPA or MPA. Use the information provided here to talk with your doctor about any symptoms you may be having and if Rituxan may be right for you. It is important to remember that Rituxan can cause side effects and not everyone responds to Rituxan in the same way. Some people experience side effects during or after their Rituxan treatment.

What is the most important information I should know about Rituxan?

Rituxan can cause serious side effects that can lead to death, including:

  • Infusion Reactions: Infusion reactions are the most common side effect of Rituxan treatment. Serious infusion reactions can happen during your infusion or within 24 hours after your infusion 
  • Severe Skin and Mouth Reactions: Tell your healthcare provider if you get any of these symptoms during treatment with Rituxan: painful sores or ulcers on your skin, lips, or in your mouth; blisters; peeling skin; rash; or pustules 
  • Hepatitis B Virus (HBV) Reactivation: If you have had hepatitis B or are a carrier of hepatitis B virus, receiving Rituxan could cause the virus to become an active infection again. Hepatitis B reactivation may cause serious liver problems, including liver failure and death. You should not receive Rituxan if you have active hepatitis B liver disease 
  • Progressive Multifocal Leukoencephalopathy (PML): PML is a rare, serious brain infection caused by a virus that can happen in people who receive Rituxan. People with weakened immune systems can get PML. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML

Please see below and the Rituxan Medication Guide for additional Important Side Effect Information, including Most Serious Side Effects.