GPA and MPA Treatment

Treatment options for GPA and MPA

There are a few different treatment options available for your active disease. Your doctor will decide which treatment is right for you based on your medical history and the severity of your disease. The goal of treatment is to reduce the inflammation and control your symptoms. 

You and your doctor may discuss different types of treatments. Talk to your doctor about what treatment options are right for you. It is important that you and your doctor weigh the risks and benefits of any medication. Although other medications are used to treat adults with Granulomatosis with Polyangiitis (GPA) (formerly known as Wegener's Granulomatosis) and Microscopic Polyangiitis (MPA), Rituxan® (rituximab) in combination with glucocorticoids is the first and only FDA-approved medicine for adults with GPA and MPA.

For important side effect information about Rituxan, please see the Important Safety Information below, and the Prescribing Information and Medication Guide.

Treatments that you and your doctor may discuss (talk with your doctor about the side effects associated with these medications):

  • Steroids: Prescribed to control inflammation and often used in combination with other medications
  • Immunosuppressive agents, such as cyclophosphamide, azathioprine and methotrexate: May be used to treat GPA and MPA, but are not FDA-approved for the treatment of GPA and MPA
  • Rituxan: When used in combination with glucocorticoids, Rituxan is the first and only FDA-approved medicine for adults with GPA and MPA. Talk to your doctor about the side effects associated with Rituxan. Individual results may vary

What is the most important information I should know about Rituxan?

Rituxan can cause serious side effects that can lead to death, including:

  • Infusion-Related Reactions: Infusion-related reactions are the most common side effect of Rituxan treatment. Serious infusion-related reactions can happen during your infusion or within 24 hours after your infusion 
  • Severe Skin and Mouth Reactions: Tell your healthcare provider if you get any of these symptoms during treatment with Rituxan: painful sores or ulcers on your skin, lips, or in your mouth; blisters; peeling skin; rash; or pustules 
  • Hepatitis B Virus (HBV) Reactivation: If you have had hepatitis B or are a carrier of hepatitis B virus, receiving Rituxan could cause the virus to become an active infection again. Hepatitis B reactivation may cause serious liver problems, including liver failure and death. You should not receive Rituxan if you have active hepatitis B liver disease 
  • Progressive Multifocal Leukoencephalopathy (PML): PML is a rare, serious brain infection caused by a virus that can happen in people who receive Rituxan. People with weakened immune systems can get PML. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML

Please see below and the Rituxan Prescribing Information and Medication Guide for additional Important Side Effect Information, including Most Serious Side Effects.